They way they put it in interviews, this was the end of the arc started in the pilot. So in a way season 1-3 was MCU-ABC Phase 1. Next season, is essentially the start of Phase 2, imo. They could re-appropriate the Secret Warriors as a task force to hunt down Daisy. Throw in some new ones, they still have Eden Fesi to introduce. Given the final scene, Deathlok would be a good candidate to appear in a bigger role and/or even lead the SW. They did kill off Andrew so you could argue Mack was safe. My gut says May. Maria is still technically wanted by the authorities and she was shielded as an employee of Stark -- if she still is on both counts is unknown. Indeed. They've pulled other characters from the movies. Nick Fury being the biggest so far.