Doogie Howser himself, Neil Patrick Harris, will be voicing Spidey in the MTV series. Lisa Loeb will play Mary Jane. The series will be a continuation of the movie, IIRC.
Although, I'd love to see a proper ending to Spider-Man:tAS. I don't count SU as part of that continuity, and wish there was something better than "Let's go get Mary Jane." The Stan Lee bit was cool, tho.