For me it would be a tie between Clancy Brown and the Young Justice Lex. The YJ one was perfect as the manipulator. There is a quote where Superman says "Lex always was a people person, he was a manipulator at heart" and this really comes through in this version. We also saw a lot of his business side as well as his political influence. The Clancy Brown Lex was and always will be my original and he was such a fun (if evil, slimy, and downright destructive) character and while we didn't get to see as much manipulation/interaction in this version we did get to see that he always had a backup plan and it was nice to see him as a straight up villain.
"Despite all logic, my feelings for you short-lived, small-brained, foolish idiots are sufficient that I have chosen to spend my life among you, instead of on my own world where my intellect would be suitable honored... because you truly are my friends.
(Legion of Super Heroes, Vol 6, Issue 11, May 2011)