Every villain under the sun has kicked the crap out of Spider-Man. He always seems to get beat, and then he uses his knowledge from defeat to beat them the second time around. That's the problem. I see Spidey as someone who has to have his ass kicked before he can kick ass. That's just my opinion from reading various comics and watching the entire animated series.
Who's beaten Spidey? I don't know of anyone, but that could just be a lack of knowledge.
"There is an idea of a Patrick Bateman; some kind of abstraction. But there is no real me; only an entity, something illusory. And though I can hide my cold gaze, and you can shake my hand and feel flesh gripping yours and maybe you can even sense our lifestyles are probably comparable... I simply... am not... there."