I thought Chowder was going to be it. But it hasn't even been two years yet and they've given it the can.
If Chowder doesn't get renewed, then I have faith in Adventure Time. It looks extremely promising. My opinions have shifted on Adventure Time since I first encountered it on Youtube almost a year ago. It was funny, but I thought it was the most poorly drawn thing I'd ever seen. As I've followed the Frederator updates for the past few months, my like for the series has increased tenfold and there's not a speck of dislike left. So far it seems to have goofy and wacky humor that I think kids and adults are both going to like.
And if Adventure Time gets the Chowder treatment, then I'm sure Cartoonstitute will spit out a series that can at least compete with Spongebob. After all, WAC! launched not only Cartoon Network's first slate of originals, but it's greatest animators who continue to fuel the network to this day.